Tag Archives: african biobank


A new study published by our partners, the AfricaBP Open Institute, showcases transformative efforts to harness biodiversity genomics and bioinformatics to drive a sustainable African bioeconomy.





The Africa BioGenome Project (AfricaBP) aims to sequence 105,000 non‑human genomes across Africa, spanning plants, animals, fungi, and protozoa, to support food security, conservation, and biotech innovation. To bridge capacity gaps, the AfricaBP Open Institute organized 31 hands‑on regional workshops in 2024 across five geographic regions, engaging participants from over 50 African countries. These sessions trained 401 African researchers in genome sequencing, gene editing, bioinformatics, molecular biology, ethics, and biobanking, strengthening local research infrastructure and skills.





A highlight case study: the proposed “1000 Moroccan Genome Project,” which illustrates economic returns from local genome sequencing. Analysis shows that a US$20 million investment over 10 years could yield US$40 million in discounted benefits and deliver a benefit–cost ratio (BCR) of 3.29—meaning every dollar invested returns more than three dollars in value—particularly across agriculture, R&D, education, and downstream sectors.





Key recommendations emerge: integrate biodiversity genomics and bioinformatics into national bioeconomy strategies, expand capacity‑building initiatives, build regional sequencing hubs, and foster ethical, inclusive data-sharing policies. Strategic investment in these domains positions African nations to capitalize on their unique biodiversity and reclaim ownership of genomic science—a powerful lever toward sustainable development and regional innovation rooted in African knowledge and priorities  .





In short, AfricaBP’s model provides a scalable path for leveraging genomic science to fuel a resilient, inclusive African bioeconomy driven by regional talent and locally generated data. Read more here.







A landmark discovery, scientists have sequenced the genome of a man buried around 4,500–4,800 years ago at Nuwayrat in Middle Egypt, marking the oldest complete genome ever recovered from the region. Likely a potter in his 60s, the man was buried in a sealed ceramic jar carved into rock, a burial that helped preserve his DNA despite Egypt’s harsh climate.





This genome confirms ancient people-to-people contact between Egypt and Mesopotamia, echoing archaeological evidence of shared pottery styles and writing systems. The Nile likely served not just as a trade route for goods and ideas, but for human migration too.





The discovery demonstrates that DNA preservation is possible and important to build a clearer understanding of Africa's genetic history.





Learn more about this research here: https://www.nature.com/articles/d41586-025-02102-y







For the first time, researchers have detected the invasive Anopheles stephensi mosquito in Gayi, a rural area in southern Niger Republic — a country already grappling with one of the world’s highest malaria mortality rates.
Genetic analysis confirmed its presence alongside native malaria vectors such as An. gambiae s.s., An. coluzzii, and An. arabiensis. The coexistence of these species has resulted in elevated biting and transmission rates, aligning with the surge in malaria cases reported in 2024.






Experts warn that without immediate investment in robust surveillance, targeted vector control, and regional collaboration, An. stephensi could spread rapidly across the Sahel and beyond. Its presence poses a serious threat to malaria control efforts, especially in vulnerable regions bordering Niger. Urgent action is needed to contain its spread and mitigate its public health impact across Africa.






Learn more: https://www.nature.com/articles/s41598-025-07389-5



After years of stalled progress, the fight against antibiotic resistance is gaining momentum. Scientists are now exploring new ways to treat infections without relying solely on traditional antibiotics, a major shift that could reshape how we manage bacterial diseases worldwide.






Thanks to support from organizations like CARB-X and GARDP, researchers are pushing forward alternatives that were once considered too risky or radical. These include therapies like bacteriophages (viruses that infect bacteria), enzymes called lysins that break down bacterial walls, and even treatments that adjust the body’s natural microbiome.






Some scientists are testing immune-based approaches and CRISPR technology to target bacteria more precisely. These ideas are still early in development, but the growing investment and interest show a renewed belief that we don’t have to stay trapped in the old cycle of resistance.
The hope is that these innovative treatments, along with better diagnostic tools and smarter trial designs, could one day offer safer, more sustainable ways to fight deadly infections, especially as antibiotic resistance continues to rise.






This shift marks a new chapter in global health, where innovation may finally help turn the tide against superbugs.
Learn more here.







New research from the University of Surrey and the University of Oxford has uncovered a reversible mechanism in TB bacteria that may explain why the disease is so hard to treat.





The study shows that Mycobacterium tuberculosis uses a process called ADP-ribosylation to tag its DNA, allowing it to pause or resume growth—a possible survival tactic against antibiotics and immune attacks. The enzymes DarT and DarG act like a molecular switch: DarT adds the tag and halts replication, while DarG removes it to restart bacterial growth.





This discovery marks the first time DNA modification has been shown to control gene expression and replication in any organism.





By manipulating this system using CRISPRi and ADPr-Seq, scientists were able to track how these tags affect gene activity and cell division, offering a new target for drug development, especially against dormant or slow-growing TB cells. With over 1.25 million deaths annually, breakthroughs like this could reshape how we treat one of the world’s deadliest infectious diseases. Learn more here.







The Moroccan Genome Project (MGP) sequenced 109 Moroccan genomes, uncovering over 27 million genetic variants, including 1.4 million new ones. This research introduces the Moroccan Major Allele Reference Genome (MMARG), providing a more accurate representation of Moroccan genetic diversity compared to global references.





By identifying unique genetic variants, MGP aims to improve precision medicine, addressing healthcare disparities for Moroccans and North Africans, especially in diseases like kidney disease, heart conditions, and diabetes.





This initiative builds on Morocco's rich genetic history and aims to create a more comprehensive genomic reference for North Africa, paving the way for better healthcare and research in the region.





Learn more here







A new landmark genetic study has uncovered important insights into breast cancer risk among South African women. The research, led by a collaborative team of scientists and published in Nature, used genome-wide association analysis (GWAS) to explore genetic variants linked to breast cancer in this historically underrepresented population.





By analyzing over 3,500 participants (including 2,485 breast cancer cases), the study identified two significant risk loci—one between the UNC13C and RAB27A genes on chromosome 15, and another within the USP22 gene on chromosome 17. These findings mark the first time these regions have been linked to breast cancer in African populations.





Interestingly, the study also found that polygenic risk scores (PRS) developed from European ancestry datasets poorly predicted risk in this group—explaining less than 1% of the variance. This underlines a growing call in the genomics community: the need for African-specific data to create more accurate and equitable tools for disease prediction and prevention.





Ultimately, this research reinforces the importance of diversity in genomic studies and highlights how African biobanks and community-centered research can reshape global health outcomes.





Want to dive deeper into this research?
Read the full article here:
https://www.nature.com/articles/s41467-025-58789-0







Yale researchers have developed an advanced CRISPR-Cas9 gene-editing system that enables simultaneous modifications across multiple genes, a breakthrough that could transform disease research and treatment development.





Unlike traditional CRISPR methods, which target single genes at a time, this new approach allows scientists to study complex genetic interactions in diseases such as cancer, autoimmune disorders, and neurological conditions.





Using sophisticated mouse models, the research team demonstrated how this enhanced CRISPR system could map genetic pathways and identify potential therapeutic targets more effectively. The ability to edit multiple genes at once provides a deeper understanding of how different mutations contribute to disease, paving the way for more precise gene-based treatments. This advancement is expected to accelerate the development of personalized medicine and improve therapies for conditions with complex genetic underpinnings.





Funded by the National Institutes of Health and the U.S. Department of Defense, this research represents a significant leap forward in biotechnology. By expanding the capabilities of CRISPR, Yale scientists have created a tool that could revolutionize genetic research, offering hope for new treatments in fields ranging from oncology to regenerative medicine.





Learn more about this research: https://www.sciencedaily.com/releases/2025/03/250320145239.htm







A new study led by researchers at Uppsala University has shed light on the deep genetic history of the Fulani people, one of Africa’s largest nomadic pastoralist populations. With over 40 million individuals spread across the Sahel and West Africa, the Fulani have long fascinated historians, linguists, and geneticists. Yet, their ancestry remained largely underrepresented in genomic research until now.





Drawing on data from more than 460 participants across seven African countries, the study reveals that the Fulani's genetic profile is a unique mosaic shaped by ancient migrations and centuries of intermingling with neighboring populations. All Fulani groups studied share a common ancestry linked to the Green Sahara period (12,000–5,000 years ago), a time when now-arid regions of Africa were lush and fertile, supporting early human settlement and pastoralism.





What’s particularly compelling is how the Fulani have preserved a shared genetic signature across vast distances, despite cultural and geographic differences. These findings don’t just contribute to our understanding of African history, they also underscore the importance of including more African populations in genomic research, which has implications for medical science, anthropology, and the global understanding of human diversity.





You can read the full article on Science Daily here: https://www.sciencedaily.com/releases/2025/02/250211134303.htm







In a historic achievement, Egypt has been declared malaria-free by the World Health Organization (WHO). This milestone is a testament to the country's unwavering commitment to combating the disease.





For decades, Egypt fought tirelessly to eliminate malaria. The country's success story began with robust surveillance, research, and community engagement. Strategic partnerships and investments in healthcare infrastructure also played a crucial role.





This achievement has far-reaching implications for Africa. Malaria remains a leading cause of morbidity and mortality across the continent. Egypt's victory demonstrates that with collective effort, African countries can overcome this challenge.





At MyAfroDNA, we're inspired by Egypt's triumph. Our mission is to bridge the gap in genetic research, promote health equity, and advance medical breakthroughs for African populations.





We believe that collaborative research, innovation, and community engagement are key to tackling Africa's health challenges.





Join the Fight Against Diseases in Africa. If you share our vision, partner with us to:






  • Advance precision medicine for African populations




  • Foster inclusive research practices




  • Drive health equity





Let's work together to create a healthier Africa.





Learn more about Egypt's milestone in combating malaria.