Tag Archives: African genetics


Recent advances published in the American Journal of Human Genetics highlight a pivotal shift in how scientists describe human populations in genetic studies — moving away from outdated racial terms toward more precise and meaningful descriptors like ancestry and ethnicity. In deepening our understanding of human genetic variation, language matters — both scientifically and ethically.

For decades, human genetics research sometimes relied on broad, socially loaded terms such as “race” or “Caucasian.” However, analyses tracking terms used in AJHG articles over time show a clear decline in the use of “race” and a rise in the use of labels like “African,” “European,” “Asian,” “ancestry,” and “ethnicity”. This shift reflects a growing recognition that continental labels and ancestry descriptors are more biologically and socially meaningful than simplistic racial categories.

This transition is not just semantic. Accurate terms improve how we design studies, interpret results and communicate findings — especially in genetics and genomic medicine, where variation is often deeply structured by geography, migration and population history rather than socially constructed groupings.

For a company like MyAfroDNA, this conversation underscores why African-centred genomics must be anchored in scientifically precise and culturally respectful language. Africa is the most genetically diverse continent on Earth, and understanding its genetic variation requires nuanced, context-specific frameworks rather than broad, imprecise categories.

By advocating for the use of ancestry and ethnicity labels rooted in deep genomic data — rather than traditional racial descriptors — the field is moving toward more accurate, inclusive and equitable genomics research. This evolution aligns with our mission: to enrich African genomic representation, empower informed interpretation, and advance science that reflects real human diversity.



A landmark study led by researchers from University College London (UCL) and published in Science Advances reveals a previously hidden depth of genetic diversity, migration, and admixture within African populations. Titled “Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture,” the research analysed 1,333 genomes from over 150 ethnic groups across Cameroon, Ghana, Nigeria, Sudan, and the Republic of the Congo.





The findings challenge the often simplistic narratives about African genetic history. The study uncovered fine-scale genetic structure within single countries, showing that even neighbouring ethnic groups may carry distinct ancestral lineages. For instance, western Cameroonian groups exhibit unique ancestry signatures reflecting the region’s long history of local kingdoms and cultural interactions.





Researchers also traced long-distance admixture events, linking populations in northern Cameroon and Sudan with distant groups, suggesting centuries of movement through trade, migration, and empire expansion. In Ghana and Nigeria, they detected intermixing patterns dating back more than 2,000 years, likely connected to shifts in climate and vegetation that encouraged population mobility and contact.





Beyond uncovering these complex patterns, the study highlights an essential truth: Africa’s genomic diversity cannot be fully understood through limited or external data. It underscores the urgency of expanding and diversifying African genomic datasets to ensure equitable representation in global genetics research.





For MyAfroDNA, this research reaffirms our mission to strengthen African-centric molecular testing and biospecimen sourcing for both research and precision medicine. Understanding these fine-scale patterns helps scientists interpret genetic variation more accurately, improving ancestry insights and health-related findings for African communities.





As Africa continues to shape the global genomic landscape, studies like this remind us that every region, community, and ancestry carries its own genetic legacy, one that deserves to be studied, respected, and represented on its own terms.





Read the full research here.



Antimicrobial resistance (AMR) poses a major threat to global health, and Africa is no exception. As pathogens evolve, our ability to treat common infections is becoming increasingly limited.





A new study published in Scientific Reports provides valuable insight into the genetic basis of AMR in Africa, focusing on Staphylococcus aureus, one of the most widespread and clinically significant bacteria.What the Study FoundResearchers analyzed 95 whole genomes of S. aureus collected from 11 African countries. The majority of these samples were human-derived, taken from blood, pus, urine, and wound sites.





Through bioinformatic analysis, they identified 33 antimicrobial resistance genes.Key findings include:Efflux pump mechanisms were the dominant form of resistance, allowing bacteria to actively expel antibiotics.Other resistance strategies included enzyme-mediated inactivation, target alteration, protection, and replacement.West and East Africa emerged as hotspots for the distribution of resistance genes, signaling the need for stronger surveillance in these regions.





These findings highlight the urgent need to expand genomic surveillance systems across the continent. Despite covering 11 countries, the study was limited by small sample sizes and lack of data from many African nations. This gap emphasizes the importance of building local capacity for sequencing, data analysis, and sample collection.For African health systems, this research serves as a reminder that combating AMR requires both global collaboration and homegrown solutions. Without comprehensive genomic data, it will be difficult to design effective treatment guidelines, track the spread of resistance, or prepare for future outbreaks.





At MyAfroDNA, we believe genomic research should be powered by African data, African expertise, and African innovation. Our mission is to provide high-quality biospecimens and molecular testing services that enable researchers to generate the insights needed to safeguard public health.AMR is a collective challenge, but with better data and stronger collaboration, Africa can take the lead in finding solutions.









Read the full publication here: https://www.nature.com/articles/s41598-025-01398-0



A groundbreaking pair of studies published in Antiquity reveals compelling genetic evidence of West African ancestry in two individuals buried in seventh-century England. The first “West African ancestry in seventh-century England: two individuals from Kent and Dorset” was led by Professor Duncan Sayer of the University of Central Lancashire, examining the female burial from Updown, Kent.






The second, focusing on the male burial at Worth Matravers, Dorset, titled Ancient genomes reveal cosmopolitan ancestry and maternal kinship patterns at post-Roman Worth Matravers, Dorset, was led by Dr. Ceiridwen J. Edwards from the University of Huddersfield.





In both cases, mitochondrial DNA traced maternal lineage to Northern Europe, while autosomal DNA showed clear affinity with present-day Yoruba, Mende, Mandenka, and Esan groups, indicating a West African paternal grandparent.

The Updown burial included a Frankish pot and spoon suggestive of Christian or Byzantine connections, highlighting continental ties, whereas the Dorset individual was interred with local artifacts and a burial companion, underscoring full local integration.





These discoveries represent the first genetic proof of sub-Saharan African connections in Early Medieval Britain, reshaping our understanding of migration, identity, and social complexity in that era.





Read more about this discovery here.







The Moroccan Genome Project (MGP) sequenced 109 Moroccan genomes, uncovering over 27 million genetic variants, including 1.4 million new ones. This research introduces the Moroccan Major Allele Reference Genome (MMARG), providing a more accurate representation of Moroccan genetic diversity compared to global references.





By identifying unique genetic variants, MGP aims to improve precision medicine, addressing healthcare disparities for Moroccans and North Africans, especially in diseases like kidney disease, heart conditions, and diabetes.





This initiative builds on Morocco's rich genetic history and aims to create a more comprehensive genomic reference for North Africa, paving the way for better healthcare and research in the region.





Learn more here







A new study led by researchers at Uppsala University has shed light on the deep genetic history of the Fulani people, one of Africa’s largest nomadic pastoralist populations. With over 40 million individuals spread across the Sahel and West Africa, the Fulani have long fascinated historians, linguists, and geneticists. Yet, their ancestry remained largely underrepresented in genomic research until now.





Drawing on data from more than 460 participants across seven African countries, the study reveals that the Fulani's genetic profile is a unique mosaic shaped by ancient migrations and centuries of intermingling with neighboring populations. All Fulani groups studied share a common ancestry linked to the Green Sahara period (12,000–5,000 years ago), a time when now-arid regions of Africa were lush and fertile, supporting early human settlement and pastoralism.





What’s particularly compelling is how the Fulani have preserved a shared genetic signature across vast distances, despite cultural and geographic differences. These findings don’t just contribute to our understanding of African history, they also underscore the importance of including more African populations in genomic research, which has implications for medical science, anthropology, and the global understanding of human diversity.





You can read the full article on Science Daily here: https://www.sciencedaily.com/releases/2025/02/250211134303.htm